Document Type

Curriculum Material

Submission Date

2024

Abstract

Background: Absolute uterine factor infertility (AUFI) affects approximately 1 in 500 reproductive-aged women worldwide, leaving those affected unable to carry a pregnancy due to the congenital or acquired absence of a functional uterus. Historically, these women have relied on alternative methods for family building, but recent advancements in uterine transplantation offer a novel opportunity for these individuals to experience pregnancy and childbirth.

Objective: To explore the evolution, feasibility, and clinical outcomes of uterine transplantation as a treatment for AUFI, focusing on the implications for fertility and pregnancy outcomes.

Methods: A review of key studies, including Brännström et al. (2014) and the U.S. Uterine Transplant Consortium’s five-year cohort study, was conducted. These studies assessed operative techniques, immunosuppression protocols, and reproductive outcomes among uterine transplant recipients, including those with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome and prior hysterectomies.

Results: Since the first successful uterine transplantation in 2014, over 90 transplants have been performed globally, with a graft survival rate of 74% at one year and 83% of recipients achieving at least one live birth. However, the procedure is not without risks, including rejection, thrombosis, infection, and increased rates of preterm delivery. Despite these challenges, uterine transplantation remains a feasible and effective option for women with AUFI who desire to carry a pregnancy.

Conclusion: Uterine transplantation represents a significant advancement in reproductive medicine, offering hope to women with AUFI. While further research is needed to optimize outcomes and reduce complications, this procedure has potential to be a life-changing option for many.

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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