Peri-prosthetic atypical femur fractures are rare. Most are associated with the use of long-term bisphosphonates and other anti-resorptive medications. This case highlights a 74-year-old female treated with approximately 13 years of bisphosphonate therapy followed by a short course of denosumab, who suffered an atraumatic peri-prosthetic fracture after a several month prodrome. This case report's objectives are to show how the prodrome presents, increase recognition of the condition and work up prior to fracture, and emphasize the need to consider drug holidays.
Bamford, Jennifer B. and Kelly, Jennifer, "Presentation of a Peri-prosthetic Atypical Femur Fracture After Long Term Anti-Resorptive Medication Use" (2023). Larner College of Medicine Faculty Publications. 13.