Date of Completion
Honors College Thesis
Department of Psychiatry
Type of Thesis
Honors College, College of Arts and Science Honors
Julie Dumas, PhD.
Eugene Delay, PhD
John Green, PhD
insulin, estrogen, menopause, fMRI
Insulin has an important role in cognition, in addition to its well-known functions in peripheral glucose metabolism. Impaired insulin signaling has been linked to the cognitive decline seen in type 2 diabetes and Alzheimer’s Disease (de la Monte & Wands, 2008). This study examined the effect of insulin on fMRI brain activation during working memory and episodic memory tasks in six postmenopausal women. The goal of this study was to understand how the hormonal change after menopause modifies insulin signaling and how this subsequently impacts fMRI brain activation and cognition. Subjects were tested under conditions of high peripheral insulin levels compared to low levels on two separate study days; these levels were manipulated by ingestion of glucose or water on either study day. We found that high peripheral insulin levels resulted in increased brain activation in both the working memory and episodic memory tasks. Results from this study suggest that insulin functionally changes cognitive processes in the brain in postmenopausal women, however further research is needed in order to understand these changes and their underlying mechanisms.
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This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
Searles, Sienna Marie, "Effects of Insulin on Brain Functioning in Postmenopausal Women" (2016). UVM Honors College Senior Theses. 117.