Date of Completion


Document Type

Honors College Thesis


Orthopaedics and Rehabilitation

Thesis Type

Honors College

First Advisor

Bruce Beynnon

Second Advisor

Susan Kasser

Third Advisor

Timothy Tourville


anterior cruciate ligament, PTOA, patellofemoral, cartilage


Post traumatic osteoarthritis is a known complication following anterior cruciate ligament reconstruction (ACLR) and is associated with changes of articular cartilage structure. This study was conducted to investigate the relationship between articular cartilage geometry and knee strength deficits of individuals four years following ACLR in a sex-specific manner. A cohort of individuals that suffered an anterior cruciate ligament injury and surgical reconstruction with a bone-patella tendon-bone autograft underwent Magnetic Resonance Imaging and thigh muscle strength testing at a four year follow up time point. Cartilage thickness and thigh muscle strength differences were analyzed through comparison of the injured limb to the uninjured limb. This study revealed that the magnitudes (area and volume) and location of the region of articular cartilage change about the patella and femur were different between male and female subjects, demonstrating the need for sex-specific analysis of the patellofemoral joint articular cartilage. Significant differences between male and female cartilage structure were seen in the female patellas and femurs. No significant differences between cases and controls were seen for male patellas or femurs.

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.