Date of Completion


Document Type

Honors College Thesis



Thesis Type

Honors College

First Advisor

Dr. Matthias Brewer


organic synthesis, drug development, lithiation, cancer, natural products synthesis, aromatic substitution


Fusarochromanone is a powerful anticancer mycotoxin exhibiting unique molecular structure and biological activity. Fusarochromanone is produced by rare strains of fusarium equiseti and is not readily accessible for study from its natural source; thus, an efficient laboratory synthesis practical for large-scale production is an attractive goal. Previously reported syntheses of Fusarochromanone are limited by prohibitively expensive starting materials and low-yielding key steps. In this work, novel approaches to Fusarochromanone synthesis using directed ortho- metalation strategies have been proposed and tested. A cost-effective, scalable synthesis of Fusarochromanone has been achieved, and groundwork has been laid that will direct future efforts to improve the developed synthesis.

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.