Date of Completion


Document Type

Honors College Thesis


Department of Medicine

Thesis Type

Honors College

First Advisor

Matthew Poynter

Second Advisor

Robert Hondal


Medium Chain Triglycerides, ketone body, liver, asthma, ketogenesis, hmgcs2


Asthma is a chronic disorder of the airways characterized by hyperresponsiveness to inhaled triggers that cause the airways to narrow, resulting in difficulty breathing. Ketone bodies, such as b-hydroxybutyrate (BHB), decrease this airway response. Ketone body concentrations become elevated via ketogenesis, the process by which fatty acids are metabolized into ketones, occurring principally in the liver through 3-hydroxy-3-methylglutaryl-CoA synthase 2 (Hmgcs2), the rate-limiting enzyme in the ketogenesis metabolic pathway. To test the importance of liver Hmgcs2 to diet-induced BHB elevations that have been associated with decreased airway responsiveness in asthma, we utilized a mouse model of inducible, liver-specific Hmgcs2 deletion.

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.

Available for download on Sunday, May 10, 2026