Thyroid Hormone Receptor Beta Decreases Expression of the Oncogene CEMIP in Thyroid Cancer
Zielinski, Justin Michael
Zielinski, Justin Michael
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Abstract
Anaplastic thyroid cancer (ATC) is one of the most lethal cancers, yet there are few therapeutic treatments that increase patient survival. Our research focuses on two proteins: cell migration-inducing protein (CEMIP), an oncogene known for promoting migration and invasion, and thyroid hormone receptor beta (TRβ), a tumor suppressor. We are investigating how TRβ expression and activation impact the expression of CEMIP in ATC cells. We have found that CEMIP is highly expressed in ATC cells, and that TRβ decreases CEMIP expression. This suggests that TRβ presence and activation may be a tumor suppressor in part by regulating CEMIP expression.
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Undergraduate
Date
2022-01-01