Do tryptophan-synthesizing bacteria modulate expression of serotonin-related proteins in the gut?
Cox, Brendan
Cox, Brendan
Citations
Altmetric:
License
0
License
DOI
Abstract
Serotonin plays a large role in the gastrointestinal system, influencing functions such as motility, secretion, and vasodilation that are essential to human health. This project utilized Bacillus subtilis for its ability to synthesize tryptophan, the precursor to serotonin. The effect of daily treatment with Bacillus subtilis on expression of serotonin related proteins in the mouse colon was measured using RT-qPCR and HPLC. Expression of serotonin related proteins in Bacillus subtilis treated mice was not significantly different than in mice treated with PBS. This result was thought to be due to the small sample size or a non-optimal treatment duration.
Description
Undergraduate
Date
2024-01-01