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Do tryptophan-synthesizing bacteria modulate expression of serotonin-related proteins in the gut?

Cox, Brendan
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Abstract
Serotonin plays a large role in the gastrointestinal system, influencing functions such as motility, secretion, and vasodilation that are essential to human health. This project utilized Bacillus subtilis for its ability to synthesize tryptophan, the precursor to serotonin. The effect of daily treatment with Bacillus subtilis on expression of serotonin related proteins in the mouse colon was measured using RT-qPCR and HPLC. Expression of serotonin related proteins in Bacillus subtilis treated mice was not significantly different than in mice treated with PBS. This result was thought to be due to the small sample size or a non-optimal treatment duration.
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Date
2024-01-01
Student Status
Undergraduate
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Type of presentation
Poster Presentation
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UVM Student Research Conference
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URI
https://hdl.handle.net/20.500.14849/8731
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Advisor(s)
Brigitte Lavoie
Department
Program/Major
Neuroscience
College/School
College of Arts and Sciences
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Life Sciences
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