Beyond CRISPR: Targeting Single Nucleotide Variants
Facemire, Jack
Facemire, Jack
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Abstract
Single nucleotide variants are mutations in a single nucleotide base that can cause genetic disorders, increase risk for cancer, or even influence drug responses. Hundreds of thousands of people around the world suffer from genetic disorders that arise from single nucleotide variants, and treatments for these disorders are limited. Current CRISPR-Cas9 technology used to edit DNA often results in many non-specific effects such as insertions or deletions. My infographic is based on the study "Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage"(Alexis C. Komor, 2016, nature.com). In this study, the authors were able to create a novel molecule that is a CRISPR-cytidine deaminase fusion capable of editing single nucleotide variants at a much higher efficiency than CRISPR-Cas9. The authors observed an increase from ~0.1-5% correction success rate to ~15-75%. With these discoveries, we are one step closer to helping hundreds of thousands of individuals struggling with life altering genetic disorders.
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Date
1/1/2026
Student Status
First Year (Graduating in 2029)
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Poster
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Biological Science
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College of Arts and Sciences
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Life Science