Characterization of Novel Dengue Antibody Derived from Vaccination
Laskey-Rigrod, Isabelle
Laskey-Rigrod, Isabelle
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Abstract
Dengue virus is part of the family Flaviviridae and infects about 50-200 million people annually. There are four disease-causing serotypes, so it is imperative that a vaccine elicits a strong response to all four. Currently, a live attenuated tetravalent dengue vaccine (TV003) has appeared effective in clinical trials, but it is unclear whether the immune response is type-specific or cross-reactive. To investigate this question, my experiment involved isolating a dengue-specific monoclonal antibody from a TV003 recipient and analyzing its characteristics. Determining the characteristics of this antibody would allow researchers to understand the specific response the vaccine generated.
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Undergraduate
Date
2023-01-01