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Three-Dimensional Fractal Analysis of Idiopathic Pulmonary Fibrosis
Wright, William
Wright, William
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Abstract
The characterization of lung tissue architecture in Idiopathic Pulmonary Fibrosis (IPF) can provide useful insights into disease presentation and progression. In this study, we propose a novel three-dimensional (3D) fractal analysis to quantify the behavior of lung tissue in both healthy and bleomycin (BLM)-induced fibrotic mouse models. The fractal dimension (FD), which is a statistical index of complexity, was calculated for each voxel in reconstructed micro-CT images of the lung samples. These values were plotted on a kernel density estimation (KDE) plot, generating a distribution of FDs for each sample. Results indicate a slight but not statistically significant difference in average FD between the control and BLM samples. Tissue densities between the two groups were also compared in Hounsfield units (HU), a radiodensity scale, revealing elevated collagen concentrations and peripheral fibrosis in the BLM groups, consistent with IPF. Due to our small sample size of only 9 mouse lungs, further conclusions about the structural differences between healthy and fibrotic lungs are impaired. However, the results suggest disparities in the organization and/or collagen density between groups. Therefore, further assessments encompassing density features into the FD may prove to be an effective mode for differentiating and/or describing healthy and IPF lungs.
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Date
2023-01-01