TRB Differentially Regulates the Glycogen Synthesis Pathway Between ATC Cell Lines
Zielinski, Justin
Zielinski, Justin
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Abstract
Anaplastic thyroid cancer (ATC) is one of the most lethal cancers, yet there are few therapeutic treatments that increase patient survival. Thyroid hormone receptor beta (TRβ), a transcription factor, acts as a tumor suppressor through several mechanisms. One mechanism is downregulating cancer metabolism. Data suggests TRβ inhibits glycogen metabolism through differentially regulating expression of proteins involved in glycogen synthesis. Understanding the relationship between TRβ and glycogen metabolism can help to delineate the importance of glycogen in cancer, to understand one mechanism in which TRβ acts to suppress tumor growth, and to discover new potential therapeutic targets for treatment of ATC.
Description
Undergraduate
Date
2023-01-01