Synthesizing an MR Contrast Agent Sensitive to Oxidative Stress
Paige, Stephen Stender, Ian
Paige, Stephen
Stender, Ian
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Abstract
Our work combines nanotechnology and medicine to better detect inflammation, a key factor in many diseases. We've developed nanoparticles that only react in the presence of inflammation, vastly improving the diagnostic power of magnetic resonance (MR) imaging. These iron oxide particles, coated in a dual polymer complex, light up on MRI when they encounter oxidative stress, a sign of inflammation. Preliminary data has demonstrated in vitro activatability, and we are currently exploring in vivo studies. This could lead to better diagnosis and tracking of treatments for inflammatory conditions, improving patient care.
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Graduate
Date
2024-01-01