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Synthesizing an MR Contrast Agent Sensitive to Oxidative Stress

Paige, Stephen
; 
Stender, Ian
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Abstract
Our work combines nanotechnology and medicine to better detect inflammation, a key factor in many diseases. We've developed nanoparticles that only react in the presence of inflammation, vastly improving the diagnostic power of magnetic resonance (MR) imaging. These iron oxide particles, coated in a dual polymer complex, light up on MRI when they encounter oxidative stress, a sign of inflammation. Preliminary data has demonstrated in vitro activatability, and we are currently exploring in vivo studies. This could lead to better diagnosis and tracking of treatments for inflammatory conditions, improving patient care.
Description
Date
2024-01-01
Student Status
Graduate
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Volume Title
Type of presentation
Poster Presentation
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UVM Student Research Conference
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URI
https://hdl.handle.net/20.500.14849/8617
DOI
Advisor(s)
Amber Doiron
Department
Program/Major
Biomedical Engineering
College/School
College of Engineering and Mathematical Sciences
Organization
Research Category
Engineering and Math Science
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