Investigating immune-stroma signaling landscape in the developing meninges
Lanser, Toby B Walker, Alec J Gazestani, Vahid Fisher, Theodore Dragon, Julie Stevens, Beth
Lanser, Toby B
Walker, Alec J
Gazestani, Vahid
Fisher, Theodore
Dragon, Julie
Stevens, Beth
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Abstract
Recent research has revealed that populations of immune cells outside of the brain parenchyma influence the brain itself. These immune cells are located in border tissues such as the meninges. The meninges host a rich and dynamic immune environment, housing innate myeloid cells and T cells. This protective tissue is also home to diverse groups of stromal cells which likely provide a niche that supports immune function in the meninges. Here, we investigate the cross-talk between immune and stromal cell populations through development and into aging in the mouse, and how known signaling pathways are altered throughout aging.
Description
Undergraduate
Date
2022-01-01