Fgfr1b in Zebrafish Retinal Development
Davin, Ryan
Davin, Ryan
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Abstract
Cellular communication, largely accomplished through the binding of ligands to receptors, is essential to proper embryonic development. Fibroblast growth factors (FGFs) are one class of these signaling molecules. The Ebert Lab has found that loss of FGF8a in zebrafish leads to smaller eyes and mispatterning of retinal vasculature, however the receptor being utilized is unknown. There are five possibilities (FGFR1a, 1b, 2, 3, and 4). Co-localization of expression suggests the most likely candidate is FGFR1b. Our hypothesis is that FGF8a (from neurons) acts through FGFR1b (on vasculature), promoting vascular branching and loss of FGFR1b will mimic the loss of FGF8a.
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Undergraduate
Date
2024-01-01