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Abl-mediated phosphorylation of conserved Semaphorin6A tyrosine residues is necessary for zebrafish retinal integrity

MacLeod, Collin
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Abstract
Sema6A and PlxnA2 are implicated in neuronal growth and migration and function as a repulsive axon guidance cue, which leads to growth cone collapse and retraction upon binding with their respective ligand pair. We have previously shown that Sema6A and PlxnA2 signaling is necessary for proper eye development. We are now exploring potential downstream signaling pathways, including non-receptor tyrosine kinase Abl mediated Sema6A phosphorylation in both mammalian cell culture and zebrafish retinal development. Here, we identify Abl mediated phosphorylation sites on Sema6A as well as functional relevance of Abl mediated phosphorylation of Sema6A in the developing retina.
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Date
2025-01-01
Student Status
Graduate
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Oral Paper Presentation
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UVM Student Research Conference
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https://hdl.handle.net/20.500.14849/8952
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Advisor(s)
Taylor Ricketts
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Program/Major
Accounting
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Rubenstein School of Environmental and Natural Resources
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Life Sciences
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