Quantification of Functional Tissue Factor Activity on Microvesicles During the Peripartum Period
Fondakowski, Meghan
Fondakowski, Meghan
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Abstract
During pregnancy, the risk of thrombotic events, such as deep vein thrombosis and pulmonary embolism, increases due to various physiological changes in the body. Microvesicles (MVs), which are small membranous vesicles shed from various cell types, including platelets, endothelial cells, and leukocytes, have been shown to increase during pregnancy and other disease states. Recently, it has been hypothesized that microvesicles bearing procoagulant molecules may contribute to this increased thrombotic risk during the peripartum period. Tissue factor, a transmembrane cofactor expressed on endothelial cells, serves as a potential target for these analyses due to its potential for initiating blood coagulation.
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Date
2024-01-01
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Undergraduate
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Microbiology
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College of Agriculture and Life Sciences
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Life Sciences