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Hippocampal Cross-Frequency Coupling in the PTEN Knockout Model for Autism-Spectrum Disorder
Piatek, Isabella
Piatek, Isabella
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Abstract
Neurodevelopmental disorders such as autism spectrum disorder (ASD) and epilepsy are thought to involve disrupted neural circuit function, potentially through altered coordination of neuronal activity. Theta-gamma cross-frequency coupling (CFC) supports hippocampal information processing by organizing activity across time, but how PTEN mutations (which are associated with ASD and epilepsy) affect these dynamics remains unclear. Using in vivo laminar electrophysiology in awake, head-fixed mice, we found that PTEN knockout animals exhibit increased high-frequency gamma modulation, region-specific differences in oscillatory power, and abnormal fast gamma coupling in animals with interictal discharges, suggesting a breakdown in entorhinal input integration. These findings link PTEN loss to heterogeneous, and in some cases pathological, hippocampal coupling patterns, implicating altered CFC as a potential mechanism underlying impaired information processing in ASD and epilepsy.
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2026-05-01
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Analyzing Cross-Frequency Coupling in the PTEN Knockout Model for ASD
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- Embargoed until 2027-05-26
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College of Arts and Sciences
Neurological Sciences
Neurological Sciences