The Contribution of Liver 3-Methylglutaryl-CoA Synthase 2 (HMGCS2) to Dietary Medium- Chain Triglyceride-Induced Ketone Body Production
Zoller, Kate
Zoller, Kate
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Abstract
Asthma is characterized by overactive responsiveness to triggers that cause airway narrowing and difficulty breathing. Ketone bodies, such as β-hydroxybutyrate (BHB), decrease this response. BHB is produced in the liver by the enzyme 3-hydroxy-3-methylglutaryl-CoA synthase 2 (Hmgcs2). Inducible liver-specific Hmgcs2-deficient and control mice were evaluated for their responses to feeding interventions that are associated with decreased airway narrowing in asthma. Fasting, ketogenic diet, and medium-chain triglycerides all increased BHB concentrations in control mice, whereas BHB was not elevated in liver Hmgcs2-deficient mice. These results support this mouse model’s utility for examining the necessity of BHB in decreasing asthma-associated airway narrowing.
Description
Undergraduate
Date
2024-01-01