Thyroid Hormone Receptor Beta protein complex in ER+ Breast Cancer
McFarland, Sydney
McFarland, Sydney
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Abstract
Breast cancer (BCa) is the most diagnosed cancer in women worldwide and the second leading cause of cancer death in the US. Estrogen receptor positive (ER+) BCa is characterized by tumor promoter estrogen receptor alpha (ERa), while our receptor of interest, Thyroid Hormone Receptor Beta (TRb), is a known tumor suppressor. TRb and ERa have several associated histone modifying proteins in common despite their differing actions. Through an investigation of protein-protein interactions, these complexes may change in the presence of hormone and synthetic hormone agonists. Their activity could amplify tumor suppression mediated by TRb to counteract the effects of ERa.
Description
Undergraduate
Date
2023-01-01