Thyroid Hormone Receptor Beta protein complex in ER+ Breast Cancer
McFarland, Sydney
McFarland, Sydney
Citations
Altmetric:
License
License
Abstract
Breast cancer (BCa) is the most diagnosed cancer in women worldwide and the second leading cause of cancer death in the US. Estrogen receptor positive (ER+) BCa is characterized by tumor promoter estrogen receptor alpha (ERa), while our receptor of interest, Thyroid Hormone Receptor Beta (TRb), is a known tumor suppressor. TRb and ERa have several associated histone modifying proteins in common despite their differing actions. Through an investigation of protein-protein interactions, these complexes may change in the presence of hormone and synthetic hormone agonists. Their activity could amplify tumor suppression mediated by TRb to counteract the effects of ERa.
Description
Date
2023-01-01
Student Status
Undergraduate
Journal Title
Journal ISSN
Volume Title
Type of presentation
Poster Presentation
Collections
Research Projects
Organizational Units
Journal Issue
Citation
DOI
Advisor(s)
Department
Program/Major
Biochemistry
College/School
College of Arts and Sciences
Patrick Leahy Honors College
Patrick Leahy Honors College
Organization
item.page.researchcategory
Life Sciences