Small Molecule Inhibition of ERK Signaling at the PAC1 Receptor
Gebhardt, Waverly
Gebhardt, Waverly
Citations
Altmetric:
License
License
Abstract
The Pac1 receptor is a GPCR preferentially activated by PACAP. When PACAP signaling is hyperactive its becomes maladaptive in the form of chronic pain and stress disorders. The Pac1 receptor is tied to Gαq and Gαs pathways and exhibits β-arrestin mediated endosomal ERK signaling. This ERK signaling is necessary for the maladaptive PACAP-Pac1 response. The goal of the study was to target the ERK signaling without effecting the homeostatic signaling. Western blots were used to quantitate the effect of various small molecules on Pac1 ERK signaling. The data show that several small molecules were able to block the ERK signaling.
Description
Date
2023-01-01
Student Status
Undergraduate
Journal Title
Journal ISSN
Volume Title
Type of presentation
Poster Presentation
Collections
Research Projects
Organizational Units
Journal Issue
Citation
DOI
Advisor(s)
Department
Program/Major
Neuroscience
College/School
College of Arts and Sciences
Organization
item.page.researchcategory
Life Sciences