The role of coregulators in TRβ-mediated tumor suppression in anaplastic thyroid cancer
LaMothe, Sadie
LaMothe, Sadie
Citations
Altmetric:
License
License
DOI
Abstract
Anaplastic thyroid cancer (ATC) is an aggressive form of dedifferentiated thyroid cancer responsible for approximately 40% of thyroid cancer-related deaths. Thyroid hormone receptor beta (TRβ), a nuclear hormone receptor, serves as a tumor suppressor in thyroid cancers and is downregulated in ATC. Lysine-specific demethylase 1 (LSD1), a potential TRβ binding partner, is upregulated in ATC and acts as a tumor promoter. These findings enable the visualization of TRβ and LSD1 colocalization in thyroid cell lines through immunofluorescence and suggest how manipulating their interactions could offer new therapeutic options for ATC patients.
Description
Undergraduate
Date
2025-06-02