Does the Cytoplasmic Tail of HIV-1 Envelope Glycoprotein Regulate Phosphorylation of Ezrin?
Senthilnathan, Megna
Senthilnathan, Megna
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Abstract
One mode of efficient Human Immunodeficiency Virus 1 (HIV-1) dissemination is the cell-to-cell transmission of viral particles between HIV-infected T cells (producers) and uninfected CD4+ T cells (targets) at transient junctions known as the virological synapse (VS). Formation of the VS is mediated by the interaction between the viral envelope glycoprotein (Env) expressed on the producer cell surface and the CD4 receptor on the target T cell. Establishment of the VS can sometimes result in membrane fusion of the two cells, forming a small multinucleated cell (syncytium). However, several host and viral factors have been identified to repress excessive cell-cell fusion, one of those being phosphorylated ezrin (p-ezrin). This F actin-binding host protein accumulates at the VS, yet the temporal regulation of ezrin phosphorylation in HIV-1 infected cells remains to be determined.
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1:00pm-3:00pm
Undergraduate
1:00pm-3:00pm
Undergraduate
Date
2019-01-01