Microtubule destabilization improves Relaxation in Working Myocardial Slices
Hancock, Emmaleigh
Hancock, Emmaleigh
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Abstract
Diastolic heart disease (DHD) affects 1:150 adults, whom are predominantly women. In individuals with DHD a clinical marker of its progression is diastolic dysfunction (DDfx), the inability of the heart to fill with blood due to increased ventricular stiffening and impaired relaxation. Previously identified increases in the cardiac microtubule network (MTN) in vitro, showed increases in stiffness and impaired relaxation. Using a novel ex vivo experimental system we studied the MTN’s role in cardiac mechanics through a force feedback system. Colchicine treatments saw an improvement in relaxation time and increase in cardiac output.
Description
Undergraduate
Date
2023-01-01