Biofilm Infection Management via Encapsulation of Pyruvate Dehydrogenase in Alginate Hydrogel Wound Dressing
Moses, Maisie
Moses, Maisie
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Abstract
Biofilm infections present formidable challenges in wound management due to their antimicrobial tolerance. This study introduces a novel hydrogel wound dressing targeting pyruvate, a key metabolite in biofilm formation and maintenance, through entrapment of pyruvate dehydrogenase (PDH). Hydrogel sheets with varied sodium alginate concentrations were synthesized with calcium chloride as a crosslinker. Through analysis of mechanical properties, swell testing, morphology, porosity, and enzymatic activity, the study characterizes the hydrogels and demonstrates effective PDH encapsulation within the sheets. Results indicate potential for biofilm management through pyruvate depletion. Future research will optimize PDH loading and assess the dressing's efficacy in biofilm studies.
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Undergraduate
Date
2024-01-01