Endoplasmic reticulum moves by hitchhiking on multiple Rab vesicles
Morrissey, Ally
Morrissey, Ally
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Abstract
Endoplasmic Reticulum (ER) movement is critical to many cellular processes, and defects in ER movement have been linked to many diseases. There are two canonical mechanisms of ER movement (sliding and tip attachment complexes), but a novel mechanism has emerged where ER tubules “hitchhike” on motile Rab-vesicles. We found that Rab-vesicle movement is required for complete ER movement, indicating that hitchhiking may be a major mode of ER transport and providing a new direction of research for connections between ER dynamics and disease
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Date
2023-01-01
Student Status
Graduate
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Cellular, Molecular and Biomedical Sciences
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Larner College of Medicine
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Life Sciences