Divergent Genetic Regulation of Nitric Oxide Production alters the Mitochondrial Metabolism, Cell survival, and Bacterial replication control in Dendritic Cells
Gullickson, Soyeon
Gullickson, Soyeon
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Abstract
The metabolic state of immune cells regulates immune effector functions and many disease states/outcomes. Dendritic cells (DCs) support the vital juncture between innate and adaptive immunity and perform myriad immune effector functions. Activated DCs induce inflammatory genes, including Nos2, which codes for the inducible nitric oxide synthase (iNOS). iNOS produces a gaseous molecule, nitric oxide (NO). We tested genetically divergent mice strains to examine the NO effect on DC immune functions. Our data showed that NO can mediate both host -protective and -cytotoxic effects by interfering pathogen replication and/or by inhibiting host mitochondrial respiration, resulting in metabolic rewiring in DCs.
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Graduate
Date
2023-01-01