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Entrapment of pyruvate dehydrogenase in alginate hydrogel sheets towards a biofilm-eliminating wound dressing

Sedighi, Omid
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Abstract
Biofilm infections challenge wound management due to their tolerence to antimicrobial treatments. Given pyruvate's role in biofilm formation, we developed a novel hydrogel wound dressing, encapsulating pyruvate dehydrogenase (PDH) within varying concentrations of alginate hydrogel to deplete pyruvate, aiming to disperse biofilms. The hydrogel demonstrated desirable mechanical properties and swelling capacity, essential for absorbing wound exudate and facilitating pyruvate-PDH interaction. Hydrogel’s structure was studied by scanning electron microscopy. Preliminary results indicate that the encapsulated PDH successfully depletes pyruvate, showing promise in controlling biofilm infections in wounds. Further research will focus on optimizing PDH concentration and conducting in-vitro studies.
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Date
2024-01-01
Student Status
Graduate
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Type of presentation
Poster Presentation
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UVM Student Research Conference
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URI
https://hdl.handle.net/20.500.14849/8702
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Advisor(s)
Amber L. Doiron
Department
Program/Major
Biomedical Engineering
College/School
College of Engineering and Mathematical Sciences
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Engineering and Math Science
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