A computational analysis of the impact of Surfactant Proteins (SP-C) on the surface tension of pulmonary lipid monolayers
Razavi, Ali (Shervin)
Razavi, Ali (Shervin)
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Abstract
Surfactant proteins play an essential role in the stabilization of the pulmonary surfactant lipid monolayer . Monolayers are single molecule thick structures assembled from phospholipids with forces balance by hydrophobic and hydrophilic interactions. Pulmonary surfactant phospholipids form a monolayer that can contracts and expands during the process of respiration. Pulmonary surfactant-associated proteins in the lung play a role in the stabilization of the surfactant lipid monolayer. The purpose of this project was to use computational models to analyze the impact of the pulmonary surfactant-associated protein SP-C on the surface tension and collapse of the lipid monolayer found in the lungs. We use local stress calculations to understand how the surfactant proteins affect the mechanical properties of the lipid monolayer. Our results validify experimental observations as they indicate that the inherent surface tension of the monolayers decreases as the number of proteins in the simulation increases.
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Date
2020-01-01
Student Status
Undergraduate
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Oral Paper Presentation
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Mathematics
Biology
Biology
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College of Arts and Sciences
Patrick Leahy Honors College
Patrick Leahy Honors College
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Biological Sciences
Engineering & Physical Sciences
Engineering & Physical Sciences