Size-Specific Nanoparticles as Treatment for Vascular Disease
Roode, Nicole
Roode, Nicole
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Abstract
In Ischemic Strokes, blood clots block blood flow to surrounding tissue leading to necrosis of cells and potentially death. One promising method of treating this condition is using vasodilators. Vasodilation occurs as the result of an influx of calcium in endothelial cells that triggers hyperpolarization of the endothelial and smooth muscle membranes. Recent work within our lab demonstrates that inorganic nanoparticles within a small size range can induce calcium uptake in the endothelium via the action of the transient receptor potential vanilloid-type 4 (TRPV4) cation channel. We hypothesize that 20 nm gold nanoparticles will trigger a vasodilation pathway through TRPV4.
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2024-01-01