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The role of RUNX1-mediated suppression of breast cancer tumorigenicity
Del Porto, Jackson R
Del Porto, Jackson R
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Abstract
Despite significant progress in therapeutic strategies dramatically improving breast cancer survival rates, late-stage metastatic breast cancer survival rates remain low. The transcription factor RUNX1 has been demonstrated to suppress breast cancer stem cells, epithelial to mesenchymal transition (EMT), and tumorigenicity. To interrogate the mechanism of suppression, we selectively and rapidly induced the degradation of RUNX1 in normal-like mammary cells to determine the immediate and putatively direct processes as well as the intermediate and long-term alterations that are critical for tumor formation. Subsequent analysis of RNA and protein expression changes provides great insight into the pathology of cancer. This study underscores the potential of selectively targeting cellular pathways to prevent tumor formation.
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2025-01-01