Transcriptomic Dysregulation in Rodent Models of ADHD and Substance Use Suggests Shared Neural Mechanisms
Van Horn, Sarah
Van Horn, Sarah
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Abstract
Attention-Deficit/Hyperactivity Disorder (ADHD) is highly heritable and increases the likelihood of developing a substance use disorder (SUD). The self-medication hypothesis of nicotine use in ADHD proposes that patients seek nicotine for its ability to improve ADHD symptoms, and ADHD patients have less success quitting, possibly related to the worsening of ADHD symptoms accompanying withdrawal (Liebrenz et al., 2014). By comparing the transcriptome of rodent models of ADHD with and without amphetamine exposure to rodents with high nicotine preference, the present analysis has led to the identification of novel genes and associated biological pathways differentially expressed in ADHD and nicotine use.
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Undergraduate
Date
2024-01-01