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The Role of Abl- and PKC-Dependent Reverse Signaling in Zebrafish Retinal Development

MacLeod, Collin
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Abstract
We have previously identified Sema6A and PlxnA2 to be necessary for eye size, eye field cohesion, and retinal lamination. Upon Sema6A and PlxnA2 binding, bidirectional signaling events revolving around Sema6A and PlxnA2 are referred to as reverse and forward signaling, respectively. Using zebrafish and cultured cells as models, we have previously characterized important features of forward signaling through PlxnA2, however, reverse signaling via Sema6A remains largely uncharted. Here we explore the functional relevance of Abl-mediated reverse signaling on retinal integrity. Together these data provide insight Sema6a reverse signaling and its role in the development of the neural retina.
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Date
2024-01-01
Student Status
Graduate
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Poster Presentation
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UVM Student Research Conference
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https://hdl.handle.net/20.500.14849/8785
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Advisor(s)
Alicia Ebert
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Program/Major
Neuroscience
College/School
Larner College of Medicine
College of Arts and Sciences
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Life Sciences
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