Hydrophosphination Substrate Scope Expansion
Tschaikowsky, Peter
Tschaikowsky, Peter
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Abstract
Hydrophosphination is an atom economical synthetic reaction that generates a phosphorus-carbon bond. However, reported examples of hydrophosphination often involve repetitively used reagents. This project aims to conduct hydrophosphination using several novel organophosphines with varying electron withdrawing/donating properties while utilizing a recently implemented copper based catalyst. This will (1) add much needed diversification to the organophosphine scope of hydrophosphination while (2) studying how electron withdrawing/donating properties affects the copper catalyst’s reactivity. All reactions in this project are carried out in a nitrogenous atmosphere in a glovebox or nitrogen line to limit side reactions with oxygen or contamination of the reaction. Along with this, extensive characterization of the hydrophosphination products are accomplished through a multitude of instrumentation in order to prove that the desired reactions occurred. Investigation is still underway for this project. It is hoped that there will be a difference in product yield that correlates with a change in electron withdrawing/donating properties of a given organophosphine substrate.
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Undergraduate
Date
2023-01-01