Determining the Relationship of Peptide’s Ramachandran φ Angle and the Raman Amide III2 Frequency
Perez, Nicholas
Perez, Nicholas
Citations
Altmetric:
License
License
Abstract
Raman spectroscopy, an inelastic light scattering technique, is a tool that can probe molecular vibrations of proteins. Raman spectroscopy can quantify a protein’s averaged Ramachandran φ-angles due to its relationship with the Amide III vibrational mode. However, a relationship between the Ramachandran φ-angle and a vibrational mode has not been determined. We developed a method to crystallize dipeptides with varying Ramachandran φ-angles to correlate the φ-angles to the Amide III vibrational mode. This relationship will be applied to enhance the structural characterization of amyloid fibril protein aggregates, which are implicated in Alzheimer’s disease.
Description
Date
2024-01-01
Student Status
Undergraduate
Journal Title
Journal ISSN
Volume Title
Type of presentation
Poster Presentation
Collections
Research Projects
Organizational Units
Journal Issue
Citation
DOI
Advisor(s)
Department
Program/Major
Biochemistry
College/School
College of Arts and Sciences
Organization
Research Category
Physical Science