HUVEC Tubular Formation on Bio-inspired Vascularization Substrate
Garcia, Luis M
Garcia, Luis M
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Abstract
While possessing many desired properties for a biomaterial capable of cell encapsulation, alginate lacks the ability to interact with mammalian cells; however, alginate can be chemically modified with RGD- peptides, which promote cell adhesion, proliferation and ingrowth. Heparin, a glycosaminoglycan naturally found in the body, plays a role in preventing the formation of a thrombosis due to its anticoagulant activity and is a component of the extracellular matrix of blood vessels that has been shown to promote the growth of endothelial cells in vitro. The aim of this study was to determine the feasibility heparin and arginyl-glycyl-aspartic acid (RGD) conjugated alginate hydrogels encapsulated with vascular endothelial growth factor (VEGF) as a wound dressing to promote vascularization. VEGF is an important component in angiogenesis that binds to heparin, and RGD promotes cell adhesion. Alginate hydrogels consisted of methacrylic anhydride (MA), RGD, and heparin, and were crosslinked with visible light. The material properties and burst pressure mechanics were evaluated to determine the structural integrity and adhesiveness of the hydrogels.
Description
9:00 AM
9:00am-11:00am
Undergraduate
9:00am-11:00am
Undergraduate
Date
2019-01-01