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Spatiotemporal Distribution of LOXL1-4 in the Endometrium During Embryo Implantation
Mulder, Thomas Sparhawk
Mulder, Thomas Sparhawk
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Abstract
Lysyl oxidase-like enzymes (LOXL1-4) belong to the lysyl oxidase family, which cross-link fibrous extracellular matrix proteins like fibrillar collagen and elastic fibers. These enzymes ultimately determine tissue strength. However, their role in the endometrium during embryo implantation remains undefined. In this study, we aimed to investigate the expression and spatial distribution of LOXL1-4 within the endometrium during embryo implantation. We utilized uterine cross sections prepared from gestation days 5 to 8 to investigate the expression and spatial distribution of LOXL1-4. Confocal imaging analysis revealed distinct expression and spatial distribution patterns of all LOXL1-4. All LOXL1-4 enzymes are localized within the decidua, although they exhibit varying expression patterns. To gain further insights, we employed an in vitro stromal cell decidualization model. This model provided compelling evidence that stromal cells serve as the primary source of LOXL1-4 during endometrial decidualization. In summary, our comprehensive analysis provides a detailed evaluation of the expression and spatial distribution, of LOXL1-4 during the process of endometrial decidualization.
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Date
2025-01-01