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Assessing the Contribution of Liver 3-Hydroxy-3-Methylglutaryl-CoA Synthase 2 (HMGCS2) to Dietary Medium-Chain Triglyceride-Induced Ketone Body Production
Zoller, Kaitlyn A. Mank, Madeleine M. Fastiggi, V. Amanda Poynter, Matthew E.
Zoller, Kaitlyn A.
Mank, Madeleine M.
Fastiggi, V. Amanda
Poynter, Matthew E.
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Abstract
Asthma is a chronic disorder of the airways characterized by hyperresponsiveness to inhaled triggers that cause the airways to narrow, resulting in difficulty breathing. Ketone bodies, such as b-hydroxybutyrate (BHB), decrease this airway response. Ketone body concentrations become elevated via ketogenesis, the process by which fatty acids are metabolized into ketones, occurring principally in the liver through 3-hydroxy-3-methylglutaryl-CoA synthase 2 (Hmgcs2), the rate-limiting enzyme in the ketogenesis metabolic pathway. To test the importance of liver Hmgcs2 to diet-induced BHB elevations that have been associated with decreased airway responsiveness in asthma, we utilized a mouse model of inducible, liver-specific Hmgcs2 deletion.
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2024-01-01