The Investigation of the Antioxidant Properties of SS-31 Analogs in Relation to Lipid Peroxidation
Davis, Mari
Davis, Mari
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Abstract
Mitochondria are found in all human cells, and they are responsible for creating the majority of ATP. The membranes of the mitochondria are easily oxidized, and this can lead to many diseases and adverse effects. This project seeks to develop an improved version of a mitochondrial targeting peptide called SS-31. The improvement will be achieved by replacing the antioxidant amino acid with an amino acid called 2-thiohistidine (2TH).The hypothesis is that peptide analogues of SS-31 containing multiple 2TH residues will prevent lipid oxidation at lower concentrations than those containing only one 2TH residue or only other antioxidant residues.
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Date
2024-01-01
Student Status
Undergraduate
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Poster Presentation
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Classics/Classical Civilization
Chemistry
Chemistry
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College of Arts and Sciences
Patrick Leahy Honors College
Patrick Leahy Honors College
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Physical Science