Characterization of APOBEC3A Regulation through Protein–protein interactions
Schiefen, Dan
Schiefen, Dan
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Abstract
My project aims to characterize the protein-protein interactions of APOBEC3A (A3A). A3A is a cytidine deaminase involved in viral innate immune response, and whose dysregulation has previously been identified in approximately 50% of all cancer genomes. Specific interacting proteins that have been identified include HEXIM1 and TAX1BP1, which are both involved in innate immune response. Characterization of how identified proteins interact with A3A may explain how their interactions may contribute to A3A-induced mutagenesis. This increased understanding would provide a basis for future research with APOBEC3A including controlling A3A regulation and reducing A3A induced cancer mutagenesis.
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Undergraduate
Date
2024-01-01