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Characterization of APOBEC3A Regulation through Protein–protein interactions

Schiefen, Dan
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Abstract
My project aims to characterize the protein-protein interactions of APOBEC3A (A3A). A3A is a cytidine deaminase involved in viral innate immune response, and whose dysregulation has previously been identified in approximately 50% of all cancer genomes. Specific interacting proteins that have been identified include HEXIM1 and TAX1BP1, which are both involved in innate immune response. Characterization of how identified proteins interact with A3A may explain how their interactions may contribute to A3A-induced mutagenesis. This increased understanding would provide a basis for future research with APOBEC3A including controlling A3A regulation and reducing A3A induced cancer mutagenesis.
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Date
2024-01-01
Student Status
Undergraduate
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Type of presentation
Poster Presentation
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UVM Student Research Conference
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URI
https://hdl.handle.net/20.500.14849/8646
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Advisor(s)
Steven Roberts
Department
Program/Major
Microbiology and Molecular Genetics
College/School
College of Agriculture and Life Sciences
Patrick Leahy Honors College
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Life Sciences
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