Observing Protein-Protein Interactions on Mesoporous Silica Nanoparticles Using STORM
Cech, Bradley
Cech, Bradley
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Abstract
Mesoporous silica nanoparticles are great candidates for nanomedicine due to their tunable pore size, high surface area, and good biocompatibility. When exposed to biological media, a two-layered shell of proteins forms around the particles, known as the protein corona (PC). This envelopment changes how the particles will behave when placed into a true biological setting. Ourfocus is on measuring the kinetic exchange of various proteins between the two layers of the PC using stochastic optical reconstruction microscopy. Understanding the composition, formation, and evolution of the PC is crucial for advancing the development of safe and effective particle-based therapies.
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Graduate
Date
2023-01-01