Understanding REV1 inhibition-dependent mechanisms of TNR instability
Allen, Lindsay P
Allen, Lindsay P
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Abstract
Trinucleotide repeats (TNRs) are prone to genomic instability in the form of expansion or contractions. This is especially problematic in specific genes where repeat expansion results in neurodegenerative disorders. Specifically, expanded CAG repeats in the HTT gene cause Huntington’s Disease. Because these repeats are unstable, their mutagenesis can be triggered by various things, including environmental factors. Here, we show that REV1, a key translesion synthesis polymerase, has a protective effect on CAG repeat lengths. When REV1 was inhibited in cells, there was increased CAG repeat instability. Additionally, REV1 inhibitor drugs JH-RE-06.NaOH and Drug 4 have a cryoprotective effect on cells.
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Undergraduate
Date
2022-01-01