Revealing two distinct molecular binding modes in polyethylenimine-DNA polyplexes using infrared spectroscopy
Diorio, Danielle
Diorio, Danielle
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Abstract
Non-viral polymeric delivery vectors have attracted significant attention due to their reduced immunogenic effects. However, their efficiency and efficacy are poorly understood. A crucial factor is the formation of the polymer-DNA complex, which should be strong enough to avoid cellular degradation, but weak enough to allow efficient DNA release. To address this, we utilized FTIR spectroscopy to develop a molecular-level study by probing the structures of two polyethyleneimine systems. Our findings provide essential insights into the behavior of these interactions at a molecular level, paving the way for designing more effective polymer systems.
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Undergraduate
Date
2025-05-29