Oxidative Inactivation of Cathepsin B in Idiopathic Pulmonary Fibrosis
Tarte, Megan
Tarte, Megan
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Abstract
Idiopathic pulmonary fibrosis (IPF) is a progressive disease characterized by repeated micro injuries to the respiratory epithelium that result in altered repair pathways. Oxidative stress has long been associated with IPF pathogenesis, although the exact mechanisms that contribute to disease progression remain unclear. Protein s-glutathionylation (PSSG), a post-translational redox modification, has been demonstrated to increase in patients with IPF in conjunction with decreased activity of glutaredoxin-1 (GLRX), a key antioxidant enzyme responsible for its reversal. While the role of Glrx in fibrosis has been extensively studied, the S-glutathionylated protein targets that are impacted by Glrx inactivation remain under investigation.
Description
Undergraduate
Date
2022-01-01