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Localization of the Receptors that Mediate the Prokinetic Effects of 5-HT4 Agonists on Propulsive Motility
Gagne, Jessica E.
Gagne, Jessica E.
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Abstract
Functional gastrointestinal disorders are very common, with a frequent symptom of these conditions being constipation. One of the most effective treatments for constipation involves 5-HT4 receptor agonists, but it is unclear as to whether they act on receptors in the mucosa or muscularis. Motility assays were performed with test compounds that activate the 5-HT4 receptor on transgenic mouse strains in which this receptor is tissue-specifically downregulated. The agonists were found to have inconsistent results on the different mouse strains, which may be a result of ineffective knockdown of the receptors.
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2023-01-01