Presenter's Name(s)

Nick John MinadeoFollow

Primary Faculty Mentor Name

Matthias Brewer

Graduate Student Mentors

Nicholas Dodge

Status

Undergraduate

Student College

College of Arts and Sciences

Program/Major

Chemistry

Primary Research Category

Engineering & Physical Sciences

Presentation Title

Toward an Efficient Synthesis of Fusarochromanone

Time

3:00 PM

Location

Silver Maple Ballroom - Engineering & Physical Sciences

Abstract

Fusarochromanone is a fungal metabolite and mycotoxin produced by Fusarium equiseti. Fusarochromanone has been shown to inhibit angiogenesis (blood vessel growth), prevent cell reproduction, and even induce apoptosis (cell death) in several types of cancer cells, including glioblastomas and melanomas. The molecular mechanisms of the bio-activity of fusarochromanone are not well understood at this time. Further research may spur development of promising anti-cancer drugs. However, fusarochromanone is not readily available in useful quantities for investigation. The goal of this project is to develop a method of synthesizing fusarochromanone simply and cheaply on a large scale so that its potential as a cancer treatment may be explored. Thus far, we have optimized an existing method to produce fusarochromanone more efficiently and are continuing to develop a new total synthesis.

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Toward an Efficient Synthesis of Fusarochromanone

Fusarochromanone is a fungal metabolite and mycotoxin produced by Fusarium equiseti. Fusarochromanone has been shown to inhibit angiogenesis (blood vessel growth), prevent cell reproduction, and even induce apoptosis (cell death) in several types of cancer cells, including glioblastomas and melanomas. The molecular mechanisms of the bio-activity of fusarochromanone are not well understood at this time. Further research may spur development of promising anti-cancer drugs. However, fusarochromanone is not readily available in useful quantities for investigation. The goal of this project is to develop a method of synthesizing fusarochromanone simply and cheaply on a large scale so that its potential as a cancer treatment may be explored. Thus far, we have optimized an existing method to produce fusarochromanone more efficiently and are continuing to develop a new total synthesis.