Primary Faculty Mentor Name

John Matthew Mahoney

Status

Undergraduate

Student College

College of Arts and Sciences

Program/Major

Neuroscience

Primary Research Category

Biological Sciences

Presentation Title

Effects of Early Life Seizures on Behavior in C57bl/6J and DBA/2J Mice

Time

3:00 PM

Location

Silver Maple Ballroom - Biological Sciences

Abstract

Childhood epilepsy has been shown to increase risk of cognitive impairments later in life. To better understand these difficulties, the early life seizure (ELS) model is used on both C57bl/6J and DBA/2J mice. The mice go through a five-day seizure protocol with four seizures a day, starting at post-natal day eleven (p11). Between p30 and p35, the behavior battery starts, which includes; fear acquisition and extinction, social interaction and novelty, and open field. Strain differences in seizure susceptibility have been found and phenotypic differences in behavior were assessed. Nissl staining for cortical lamination and fluorescent staining astrocytes is used in addition to the behavioral data.

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Effects of Early Life Seizures on Behavior in C57bl/6J and DBA/2J Mice

Childhood epilepsy has been shown to increase risk of cognitive impairments later in life. To better understand these difficulties, the early life seizure (ELS) model is used on both C57bl/6J and DBA/2J mice. The mice go through a five-day seizure protocol with four seizures a day, starting at post-natal day eleven (p11). Between p30 and p35, the behavior battery starts, which includes; fear acquisition and extinction, social interaction and novelty, and open field. Strain differences in seizure susceptibility have been found and phenotypic differences in behavior were assessed. Nissl staining for cortical lamination and fluorescent staining astrocytes is used in addition to the behavioral data.