Presenter's Name(s)

Skye LockwoodFollow

Primary Faculty Mentor Name

Benedek Erdos

Project Collaborators

Zach Einwag (Laboratory Technician Mentor) and Daniella Thorsdottir (Graduate Student Mentor)

Secondary Mentor NetID

amoriell

Secondary Mentor Name

Tony Morielli

Graduate Student Mentors

Daniella Thorsdottir

Status

Undergraduate

Student College

College of Agriculture and Life Sciences

Program/Major

Animal Science

Second College (optional)

Graduate College

Second Program (optional)

Pharmacology

Primary Research Category

Biological Sciences

Secondary Research Category

Health Sciences

Presentation Title

Effect of brain-derived neurotrophic factor on the density of hippocampal microvasculature

Time

11:00 AM

Location

Silver Maple Ballroom - Biological Sciences

Abstract

Alzheimer’s disease (AD) poses a significant threat to public health both nationally and globally, yet remains without any proven preventions, treatments or cures. It has been identified that both chronic stress and impaired cardiovascular function are among the factors involved in the pathogenesis of dementias such as AD. Brain-derived neurotrophic factor (BDNF), which is regulated by the hypothalamic-pituitary-adrenal (HPA) axis in response to chronic stress, has been found to have lowered hippocampal expression in those with AD (8). The goal of this research project is to identify the effects of BDNF on the density of microvasculature in the hipppocampus. Understanding the role of BDNF in the density and structure of microvasculature in brain regions critical to memory and cognitive function such as the hippocampus will help further elucidate the underlying mechanisms that lead to AD and related vascular dementias.

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Effect of brain-derived neurotrophic factor on the density of hippocampal microvasculature

Alzheimer’s disease (AD) poses a significant threat to public health both nationally and globally, yet remains without any proven preventions, treatments or cures. It has been identified that both chronic stress and impaired cardiovascular function are among the factors involved in the pathogenesis of dementias such as AD. Brain-derived neurotrophic factor (BDNF), which is regulated by the hypothalamic-pituitary-adrenal (HPA) axis in response to chronic stress, has been found to have lowered hippocampal expression in those with AD (8). The goal of this research project is to identify the effects of BDNF on the density of microvasculature in the hipppocampus. Understanding the role of BDNF in the density and structure of microvasculature in brain regions critical to memory and cognitive function such as the hippocampus will help further elucidate the underlying mechanisms that lead to AD and related vascular dementias.