Presentation Title
Investigating the Protein-Coding Potential of a lncRNA
Abstract
Study in the field of genetics has identified long non-coding RNA (lncRNA) as a novel class of molecule that participates in cell function in diverse and convoluted ways. The mouse gene U90926 is thought to produce one such lncRNA molecule in activated macrophage cells. Macrophage activation is a key component of the inflammatory response, and is known to influence the onset of autoimmune disorders. My project investigates the protein-coding potential of U90926. Characterization of the molecule(s) produced by this gene will indicate its mechanistic role in regulating macrophage activation. Improved understanding of how this process influences the larger immune response could prompt innovation of new therapies for autoimmune diseases.
Primary Faculty Mentor Name
Dimitry Krementsov
Secondary Mentor Name
Karolyn Lahue
Graduate Student Mentors
Bristy Sabikunnahar
Faculty/Staff Collaborators
Bristy Sabikunnahar (Graduate Student Mentor)
Status
Undergraduate
Student College
College of Arts and Sciences
Program/Major
Biochemistry
Primary Research Category
Biological Sciences
Investigating the Protein-Coding Potential of a lncRNA
Study in the field of genetics has identified long non-coding RNA (lncRNA) as a novel class of molecule that participates in cell function in diverse and convoluted ways. The mouse gene U90926 is thought to produce one such lncRNA molecule in activated macrophage cells. Macrophage activation is a key component of the inflammatory response, and is known to influence the onset of autoimmune disorders. My project investigates the protein-coding potential of U90926. Characterization of the molecule(s) produced by this gene will indicate its mechanistic role in regulating macrophage activation. Improved understanding of how this process influences the larger immune response could prompt innovation of new therapies for autoimmune diseases.