Presentation Title

Supramolecular Shape-Control with Chirality-Assisted Synthesis

Abstract

The organic world depends on proteins, which are complex polymers that have shape-determined functionality. Despite understanding the properties that dictate protein polymerization, predicting protein structure de novo remains a frontier in protein chemistry. This presentation summarizes recent advancement in chirality-assisted synthesis (CAS), a technique that accomplishes sequence-defined polymers via manipulating the chirality of the monomers. The following work describes both linear and non-linear polymers that exhibit directionality, akin to that observed in biomolecules. This has served as framework for recent work in the Schneebeli Group aimed to identify a novel, synthetic methodology that generates shape-controlled polymers.

Primary Faculty Mentor Name

Severin Schneebeli

Graduate Student Mentors

Jessica Bocanegra

Status

Undergraduate

Student College

College of Arts and Sciences

Program/Major

Biochemistry

Primary Research Category

Engineering & Physical Sciences

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Supramolecular Shape-Control with Chirality-Assisted Synthesis

The organic world depends on proteins, which are complex polymers that have shape-determined functionality. Despite understanding the properties that dictate protein polymerization, predicting protein structure de novo remains a frontier in protein chemistry. This presentation summarizes recent advancement in chirality-assisted synthesis (CAS), a technique that accomplishes sequence-defined polymers via manipulating the chirality of the monomers. The following work describes both linear and non-linear polymers that exhibit directionality, akin to that observed in biomolecules. This has served as framework for recent work in the Schneebeli Group aimed to identify a novel, synthetic methodology that generates shape-controlled polymers.